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Brain Builder | Painkiller 2.0 | Ferntastic

Issue #139

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Happy year of the dragon! 🐲 

To celebrate, we’ll check out one of my favorite dragons before diving into recent groundbreaking science news.

-Steve, of house casualSTEM, Dovahkiin, and big fan of dragons

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Brain Builder

Axolotls are so smart, they can regrow their brains. Researchers mapped the telencephalon region, then removed a section to learn exactly how these dragon-like salamanders regenerate brain tissue.

  • Telencephalon has a large impact on animal behavior/cognition

  • Phase 1: Specialized progenitor cells begin healing

  • Phase 2: Those cells turn into neuroblasts (newly discovered in axolotl)

Regeneration is completed in phase 3, when neuroblasts become the exact neurons that were removed. Learning how these slippery salamanders build their brains back could lead to advances in regenerative medicine research.

Quick! (vote)

Which would you rather ride?

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Check out last week’s results in “Unnatural Selection” below

Painkiller 2.0

Non-addictive pain medication may be coming soon. Vertex Pharmaceuticals recently wrapped up Phase 3 clinical trials of its non-opioid painkiller, VX-548.

  • Blocks NaV1.8 sodium channel

  • Stopping pain signals at the PNS (peripheral nervous system)

  • Effective for surgical and non-surgical pain

By combatting pain through the PNS, VX-548 avoids reward/pleasure areas of the central nervous system targeted by opioids. Vertex will file for FDA approval by mid-2024 to treat moderate-to-severe acute pain.

Ferntastic

Some plants don’t believe in wasting dead leaves. At least one species of fern, Cyathea rojasiana, uses its drooping fronds as roots.

  • Accidentally discovered by researchers clearing debris

  • Leafy roots soak up additional nutrients 

  • Creating an advantage over neighboring tall plants

Frond feeding abilities were conferned by replication in a lab using nitrogen enriched soil. Future studies will uncover how leaf-root absorption works and whether it involves intra-root fungi. Soo what’s the root cause?

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Clickables

📷️ Polar bear naps his way to best photo

Unnatural Selection

Last week: “Which Finding Nemo character would you rather be?”

14% dory, 86% crush

First the results were like “whoa”, and then they were like “WHOA!”, and then they were like “whoooa”.

Make sure you vote up top for next week’s “Unnatural Selection”!

st3v on site

Frequent Flyer

st3v riding an axolotl

created using DALL-E 4 + Steve’s editing skillz

Even though he’s technically a tiger, st3v is going all out celebrating the year of the dragon!

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