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Salamander People | Titanium Teeth | Brain Builder
Issue #209 - Axolotls!
Welcome to the weekend! Glad you could make it.
—Steve 🥳
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Salamander People
Human limb regeneration could be rebranded axolotl tricks. Researchers discovered how the beloved creature knows what and where to regrow.
Axolotl = salamander with remarkable regeneration ability
Gradient chemical signals helped map tissue identity
Retinoic acid tells cells where they are in the body
Blocking these signals disrupted limb regrowth, suggesting vertebrate regeneration requires combining positional memory and localized cues. Further research could lead to human regeneration after traumatic injuries. Or let us grow axolotl hair.
Check out last week’s results in “Unnatural Selection” below
Titanium Teeth
Maybe you can grow “new” teeth as an adult? Titanium dental implant expands into place and feels more like the real thing.
No screws required
Bonds with gums and jawbone
Reduces trauma and eliminates the need for bone cement
Animal studies showed stronger integration and lower inflammation. Keep brushing your teeth though, researchers still need to test larger animals before moving on to clinical trials. Tooth fairies are gonna be rich!
Since we’re on a regrowth kick this week, let’s look back on how axolotl’s regenerate their thinkers 👇️
Brain Builder
Axolotls are so smart, they can regrow their brains. Researchers mapped the telencephalon region, then removed a section to learn exactly how these dragon-like salamanders regenerate brain tissue.
Telencephalon has a large impact on animal behavior/cognition
Phase 1: Specialized progenitor cells begin healing
Phase 2: Those cells turn into neuroblasts (newly discovered in axolotl)
Regeneration is completed in phase 3, when neuroblasts become the exact neurons that were removed. Learning how these slippery salamanders build their brains back could lead to advances in regenerative medicine research.

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Clickables
🦑 Antarctic squid filmed alive for the first time
🔬 Researchers force HIV out of hiding
❓️ Good science always requires ammonium hydroxide (xkcd)

Unnatural Selection
Last week: “How did you pronounce "muon" before today?”

Steve made this in Procreate
In an alternate Poke-verse, Moo and Mootwo mystified fans of the original 151.
Make sure you vote up top for next week’s “Unnatural Selection”!

st3v on site
st3v-alotl

Steve made this in Procreate
It’s not just asking a lotl questions, st3v asks the right ones at the right…well, he certainly asks a lotl questions!

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